Irina M Shapiro Selected Research

PND 1186

8/2017	Inhibition of FAK kinase activity preferentially targets cancer stem cells.
1/2017	The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.
1/2016	Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
5/2014	Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship.

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Irina M Shapiro Research Topics

Disease

7	Neoplasms (Cancer) 08/2017 - 08/2011
2	Breast Neoplasms (Breast Cancer) 08/2017 - 08/2011
2	Adenocarcinoma 01/2017 - 01/2016
2	Malignant Mesothelioma 05/2014 - 02/2014
1	Triple Negative Breast Neoplasms 08/2017
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2016
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2015
1	Neurofibromatosis 2 (Neurofibromatosis Type II) 05/2014
1	Ascites 02/2014

Drug/Important Bio-Agent (IBA)

4	PND 1186IBA 08/2017 - 05/2014
3	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2017 - 05/2014
2	Phosphotransferases (Kinase)IBA 08/2017 - 01/2017
2	AsbestosIBA 05/2014 - 02/2014
1	defactinibIBA 08/2017
1	Gemcitabine FDA Link 01/2017
1	130-nm albumin-bound paclitaxelIBA 01/2017
1	Proteins (Proteins, Gene)FDA Link 01/2017
1	Collagen Type I (Type I Collagen)IBA 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Cisplatin (Platino)FDA LinkGeneric 01/2015
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2015
1	VS-5584IBA 01/2015
1	Aldehyde DehydrogenaseIBA 05/2014
1	Neurofibromin 2 (Merlin)IBA 05/2014
1	Phenobarbital (Luminal)FDA Link 08/2011
1	Messenger RNA (mRNA)IBA 08/2011

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 08/2017 - 05/2014
1	Oral Administration 08/2017
1	Immunotherapy 01/2016
1	Therapeutics 01/2016
1	Injections 02/2014
1	Intraperitoneal Injections 02/2014